Registered Nurses Salary in Southeast Missouri

In Southeast Missouri, registered nurses typically earn a median annual salary of $75,510, which translates to about $36.30 per hour. This figure is notably below the national median for registered nurses, which stands at $93,600 annually as reported by the Bureau of Labor Statistics (BLS) in May 2025. When compared to local household incomes, the earnings for registered nurses generally align with or exceed many other occupations within the region, positioning them as a critical component of the healthcare workforce in Southeast Missouri's economic landscape.

Entry-level registered nurses in Southeast Missouri can expect salaries starting at approximately $50,820 annually, reflecting the 10th percentile. As they gain experience and expertise, earnings increase significantly, with those at the 25th percentile earning about $62,280 per year. Veterans in the field, represented by the 75th percentile, earn around $82,390, while top earners (90th percentile) can make up to $98,420 annually. The disparity between entry-level and experienced nurses is primarily driven by factors such as specialized skills, years of service, certifications, and responsibilities within their roles. Additionally, geographical demand for healthcare services and the specific needs of local hospitals or clinics contribute to these salary variations.