Nurse Practitioners Salary in St. Louis, MO-IL

In St. Louis, MO-IL, Nurse Practitioners earn a median annual salary of $129,390, which is comparable to the national median of $129,210 for the same occupation. This income level positions Nurse Practitioners significantly above the local area's median household income of $78,225. Such a disparity highlights the specialized skills and education required in this field, as well as the critical role that Nurse Practitioners play within the healthcare system. The concentration of these professionals in St. Louis-IL is notable, with an estimated 3,360 employed in the region as of May 2025, reflective of both the demand for advanced nursing services and the relatively low local unemployment rate of 3.70%.

Entry-level Nurse Practitioners in St. Louis, MO-IL typically earn around $96,590 annually, which is close to the 10th percentile mark. As experience accumulates, their earnings increase substantially; those at the 25th percentile make about $113,730 per year, while experienced practitioners reaching the 75th percentile can expect to earn approximately $149,990 annually. The highest earners in this field, at the 90th percentile, bring home around $151,870 a year. This earnings progression is driven by several factors, including years of experience, specialized certifications or subspecialties, and the demand for healthcare services within specific regions. Additionally, institutional settings versus private practice can also influence salary levels, with some environments offering higher compensation packages that include benefits beyond base salary.